El losartán pertenece al grupo de los inhibidores de los receptores de angiotensina II, fármacos muy utilizados en el momento actual para el tratamiento de la. Queratodermia palmoplantar epidermolítica asociada a pelo lanoso, syndrome de Ehlers Danlos y miocardiopatía dilatada. Gaceta Dermatológica Ecuatoriana. Dermatol. peru. ; 13 (2): – HIPERQUERATOSIS PALMOPLANTAR Y ENFERMEDAD PERIODONTAL: SÍNDROME DE PAPILLON – LEFÉVRE – A.

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Management and treatment Management of the skin manifestations requires topical emollients, keratolytics including salicylic acid and urea and oral retinoids acitretin, etretinate, and isotretinoin.

SJR uses a similar algorithm as the Google page rank; it provides a quantitative and qualitative measure of the journal’s impact. If you are a member of the AEDV: On the other hand, atypical forms of dermatophytosis have been linked to AIDS. Lateral cephalogram showed no evidence of intracranial calcification.


The syndrome of palmar-plantar hyperkeratosis and premature periodontal destruction of the teeth J Pediatr ; The patient’s tongue was bright and smooth with no papillae and white plaques on the oral mucosa consistent with the diagnosis of oral candidiasis.

Amale child aged 8 years presented to the Department of the Paediatric Dentistry, Vishnu Dental College, with a complaint of loose teeth and painful swollen gums.

Subscribe to our Newsletter. Severe periodontal destruction is a typical radiographic finding in PLS patients 5. Contact with the reservoir of infection is relevant due to dissemination, which explains why the study of the patient’s close contacts is essential to identify possible sources of reinfection since recurrences are frequent in these patients.

Keratosis palmoplantaris-periodontopathia-onychogryposis syndrome Palmoplantar hyperkeratosis-periodontopathia-onychogryposis syndrome Palmoplantar keratoderma-periodontopathia-onychogryposis syndrome Prevalence: Acitretin for Papillon-Lefevre syndrome in a five-year-old girl.

To improve our services and products, we use “cookies” own or third parties authorized to show advertising related to client preferences through the analyses of navigation customer behavior. Bacterial studies of plaque at the site of the lesion in PLS showed a flora similar to that of periodontitis and was composed basically of virulent Gram-negative anaerobic pathogens such as Porphyromonas gingivalis, Prevotella intermedia and Actinomyces actinomycetemcomitans 5, 9.


Males and females are equally affected with no racial predominance 4, 5. HMS is rare with less than cases reported in the literature so far. However, there is little evidence of antibiotic therapy having an effect on the prognosis of the dentition as no controlled trials have been carried out.

Ten years before, similar symptoms were treated in another medical service with clinical improvement. A peculiar deformity of the fingers tapered, pointed phalangeal ends and a claw-like volar curve is typical. Dermatologic and oral findings in a cohort of 47 patients with Papillon-Lefevre syndrome. The documents contained in this web site are presented for information purposes only.

A scalp biopsy revealed follicular fungal invasion and Majocchi’s granuloma. Consistent with this finding, panoramic radiograph in the present case showed severe resorption of alveolar bone giving the teeth a “floating-in-air” appearance on dental X-ray film.

The diagnosis could be crusted scabies or dermatophytosis.

However, the scrapings from the right arm and the palmar hyperkeratosis were subjected to fungal culture wich revealed septate hyaline hyphae growth with tear-drop-shaped microconidia and cigar-shaped macroconidia palmopllantar transverse septa, which led to identify the isolate as Trichophyton tonsurans. Histopathology revealed acanthosis and hyperkeratosis with fungal hyphae present in the stratum corneum arm and right eyelid.

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Patients with HMS have increased susceptibility to infections. The hands are also affected but to a lesser degree 2, 5. Autosomal dominant palmoplantar keratoderma with congenital alopecia PPK-CA is a rare genetic skin disorder characterized by absence of scalp and body hair and palmoplantar keratoderma, without other hand complications. Haim-Munk syndrome HMS is characterized by palmoplantar hyperkeratosis, severe early-onset periodontitis, onychogryposis, pes planus, arachnodactyly and acroosteolysis.

J Dermatol ; HIV patients usually have superficial mycoses in many stages of the disease. After exfoliation, the inflammation subsides and the gingiva appears healthy. Multiple periodontal abscesses, pathologic migration and moderate to intense mobility affecting all the teeth were seen. Summary and related texts.

Ten years before, similar symptoms were treated in another medical service with clinical improvement. NeonatalInfancy ICD Periungueal involvement is typical, leading to secondary nail dystrophy. The dermatologist prescribed acitretin 20 mg orally daily for the initial 3 months and then 10 mg orally per day for the next two months. SRJ is a prestige metric based on the idea that not all citations are the same. The importance of early diagnosis of PLS-associated periodontitis and use of appropriate treatment methods should be recognized.


The case described here showed these classic events of gingivitis, periodontitis and precocious loss of deciduous and several permanent teeth by the age of 8 years. Transmission appears to be autosomal dominant. Specialised Social Services Eurordis directory. The majority of reported cases are descendants of a few consanguineous families from a religious isolate in Cochin, India.

Palmoplantra the present case, the diagnosis of PLS was made primarily based on the clinical, radiological and dermatological features besides analysis of laboratory tests. Palmo-plantar hyperkeratosis associated with losartan.

The lesions may be atypical, extensive and severe. General physical examination revealed bilateral yellow coloured hyperkeratotic areas on the soles and to a lesser extent in the palms Fig. All results were within normal standards for age and gender of the patient. Successful periodontal management of PLS palmoplanhar remains challenging. Direct examination and culture for fungi from skin scraping from two hipperqueratosis sites were performed.

The patient’s elbows and knees were not affected. Synovectomy has been shown to alleviate the inflammation associated with destructive arthritis but may lead to loss in the range of the joint motion. You can change the settings or obtain more information by clicking here.

The left mandibular first permanent molar appeared almost entirely out of its socket without any bone support giving the tooth a “floating-in-air” appearance Fig.